Tuesday, March 11, 2014

SC.16.3: Describe the basic process of DNA replication and how it relates to the transmission and conservation of the genetic information.

Teacher Demo: A-T G-C White board

Subject
Integrated Science 2
Theme
DNA Replication (Lesson 3)
Grade
10th
Duration of lesson
90 min
Materials
-Smart Board
-Handouts (DNA skeleton notes + DNA scavenger hunt)
-Pencil
-Notebook
Common Core Standard(s)
SC.16.3: Describe the basic process of DNA replication and how it relates to the transmission and conservation of the genetic information.
Lesson/Instructional Objective(s)
After the power point presentation of chapter 13.3 students will complete Day 1 of the worksheet (DNA replication) with 70% accuracy (7/10).
·                                 Students will recognize that a substance called DNA carries genetic information in all organisms, and changes (mutations) in DNA can be helpful or harmful to an organism.
·                                  
·                                 Students will recognize that all organisms have a substance called DNA with unique information.
·                                  
·                                 Students will recognize similarities in characteristics of plants and animals of the same type (species).

Hook/Anticipatory Set

(How will you motivate the students?)

-Stop after Bill removes DNA strand from cell!
-Since DNA is a very abstract concept I thought seeing it with the naked eye (thanks to Bill Nye) would get them excited to learn and more open to the concept of replication, translation and protein synthesis.
Procedures


1)      Class will begin with a Bell ringer where students will fill out a Venn diagram comparing and contrasting meiosis and mitosis. This should be very simple because last class the students were required to write an essay doing the exact same thing. While they do so videos showing mitosis, meiosis and asexual reproduction will be shown (approx. 1 min each) in order to help jog their mind in case they forgot over the weekend. (5-8min)
2)      Students will be given a pretest covering chapter 13 (standards: SC16.3-5) (20 min.).
3)      After the pre-test tudents will be presented with the end game (aka incentive) for the next two chapters, which is Codon bingo. I will explain to them that if they do not pay attention and work hard these next two days we will play bingo. The only way you can play if you understand the process of replication, transcription and translation. (10 min)
4)      A presentation covering replication and transmission. (20 min)
5)      Students will then work on Day 1 (part 1) of the DNA scavenger hunt. Students will get used to working with base pairs. (20 min.)

*Filler = For students who finish early I will briefly touch on the basics of transcription (Uracil instead of Thymine) and allow them to begin transcribing the DNA into RNA sequences.
Assessment of learning Outcomes

(This should have been identified in the objective.)

Test and quizzes are only one type of assessment and are not the best way to check for understanding.

(Unit plans should have an informal assessment)


After the power point presentation of chapter 13.3 students will complete Day 1 of the worksheet (DNA replication) with 70% accuracy (7/10).

Student progress will be monitored informally throughout the activity.

Students are also responsible for filling out skeleton notes for a participation grade (80% accuracy).
Closure

(How will you summarize what you have discussed?)

-This animation is a good representation of the DNA replication process, a very good summary of the lesson.
Accommodations and Modifications for
ELLs



Level 1-3
YouTube closed captioning (preview before), Translated text (run by para for accuracy), frequent parent contact, hands on activities, graphs, drawing figures, samples of completed work, groups work

Level 4-5
Frequent parent contact, hands on activities, graphs, drawing figures, samples of completed work, groups work
Accommodations and Modifications for
ESE


Can record lectures (with awareness of instructor), extra time of test, hands on activities, group work, Use charts, tables, and graphic organizers, skeleton notes, translating key concepts.
Extensions for Gifted Students
This lesson can be combined with the RNA/protein synthesis lesson (4) and the bingo game used in the RNA lesson can be removed and used as a study session practice. Also question 11 will be required, whereas the lower level students will use #11 as extra credit
Possible connections to other content areas
Math – deciphering tables and decoding


 Name: ______________________________  Period: _______
DNA Scavenger Hunt
Day 1 –Replicate the DNA (A-T & G-C)
Day 2 – Transcribe and Translate into RNA and Amino Acids (letters) *Remember: in RNA Thyamine is replaced by Uracil! (A-U T ) (G-C)
                       
                                   DNA  →    GCA        AAT       CTC         CAG        TAT      AAT
     Item #eg. - Replication  →    CGT        TTA       GAG        GTC        ATA       TTA     
                             mRNA  →    GCA        AAU       CUC        CAG        UAU       AAU
                                   Letter  →      B              E             N             I               C            E              = “Be nice!”
           
                                                                                                                                               

DNA  -
Item #1 – ATA TTA GTA GTG TAC ACG TTC GAG TTG
RNA -




DNA -
Item #2 – TAT TTA ATA ACA AAA GAC GTT ATG AAG GTA TAC TTG GAA ATA GTC GTA
RNA-




DNA-
Item #3 – ACC AAA TGT ATG ACG
RNA-





DNA -
Item #4 – AGA ATA GTT TTA AAT ATG TTG
RNA -





DNA-
Item #5 – CTA GTG GTC TAC CTG GTA TTC TAC
RNA-





DNA-
Item #6 – CTG GTT TGA TTA GCG TTC GTA GTG AAG GGA CGT GTC GTG GTA
RNA-




DNA-
Item #7 – TCG ATG ACG TTT TTC GTA GTC GCC
RNA-






DNA-
Item #8 – TCG ATA GTT TTG GAC ATG TTA CTG TTT GTA GCA AAA CGT GTG TTG
RNA-






DNA-
Item #9 – ACG AAA GAA GCG TCG AAA GAC GTT TGT GTC CAA TTG GGA
RNA-








DNA-
Item #10 – TAC CGA GGG TAC GTA TTA TAC TTG GAG
RNA-



Item #11: Working Backwards! Create your own word (at least 5 letters) by translating the letters of your word into RNA and transcribe the RNA into DNA then replicate into your second strand of DNA.











First mRNA codon letter
Second mRNA codon letter

U

C

A

G

Third mRNA codon letter


U
UUU     a

UCU      s

UAU      c

UGU      h
U
UUC      a
UCC      s
UAC      c
UGC      h
C
UUA      n
UCA      s
UAA      g
UGA      g
A
UUG      n
UCG      s
UAG      g
UGG      w
G











C
CUU      n
CCU      r
CAU      l
CGU      d
U
CUC      n
CCC      r
CAC      l
CGC      d
C
CUA      n
CCA      r
CAA      i
CGA      d
A
CUG      n
CCG      r
CAG      i
CGG      d
G











A
AUU      m
ACU      v
AAU      e
AGU      s
U
AUC      m
ACC      v
AAC      e
AGC      s
C
AUA      m
ACA      t
AAA      o
AGA      d
A
AUG      p
ACG      t
AAG      o
AGG      d
G











G
GUU      z
GCU      u
GAU      f
GGU      k
U
GUC      z
GCC      u
GAC      f
GCC      k
C
GUA      y
GCA      b
GAA      j
GGA      k
A
GUG      y
GCG      b
GAG      j
GGG      k
G









a = phenylalanine          b & u = alanine          c = tyrosine            d = arginine              e = asparagine
f = aspartic acid             g = stop codon          h = cystenine           i =  glutamine          j = glutamic acid
k = glycine                      l = histidine              m = isoleucine         n = leucine              o = lysine
p = methionine               r = proline                 s = serine              t & v = threonine       w = tryptophan
y & z = valine
***a-z = names of 20 amino acids


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